The roots of fatigue
New study uncovers new factors at play in chronic fatigue syndrome
By Morgan Sherburne
The mechanism that causes high-performance athletes to “feel the burn” turns out to be the culprit in what makes people with chronic fatigue syndrome feel exhausted by the most common daily activities.
In fact, the neural pathways that transmit feelings of fatigue to the brain might be to blame. In those with chronic fatigue syndrome, these pathways do their job too well, according to a study UF researchers recently published in the journal Pain.
The findings also provided the first evidence that peripheral tissues, such as muscles, contribute to feelings of fatigue. Determining the origins of fatigue could help researchers develop therapies or identify targets for those therapies.
In the study, researchers focused on the role of muscle metabolites, including lactic acid and adenosine triphosphate, or ATP, in the disease. Released when a person exercises his or her muscles, these metabolites seem to activate neural pathways, which the researchers say seem to be much more sensitive in patients with chronic fatigue syndrome than in patients without the disease.
Chronic fatigue syndrome, which the Institute of Medicine recently renamed systemic exertion intolerance disease, or SEID, is characterized by extreme chronic fatigue. Because its chief symptom — fatigue — is often associated with many other diseases, it can be difficult to diagnose SEID for the more than 1 million people who actually have the disease, according to the Centers for Disease Control and Prevention. The disease has no root medical cause, and researchers don’t know what triggers it. But they are studying aspects of the disease to figure out ways to treat it.
“What we have shown now, that has never been shown before in humans, is that muscle metabolites can induce fatigue in healthy people as well as patients who already have fatigue,” said Roland Staud, M.D., a professor of rheumatology and clinical immunology in the College of Medicine and the paper’s lead author.
During exercise, muscles produce metabolites, which are sensed by metaboreceptors that transmit information via fatigue pathways to the brain, according to the researchers. But in patients with SEID, these fatigue pathways have become highly sensitive to metabolites and can trigger excessive feelings of fatigue.
“For most of us, at the end of strenuous exertion we feel exhausted and need to stop — but we will recover rapidly,” Staud said. “However, these individuals tire much more rapidly and sometimes just after moving across a room, they are fully exhausted. This takes a toll on their lives.”
Staud and co-author Michael E. Robinson, Ph.D., a professor in the department of clinical and health psychology in the College of Public Health and Health Professions, recruited a group of 39 patients with SEID and 29 participants without the disease. The researchers asked the participants to don a blood pressure cuff just above their elbows on their dominant side, pick up a spring-loaded device and squeeze it to 100 percent of their maximum capacity, which was measured by a dial.
With research assistants encouraging them, the study participants then squeezed the device so that the dial showed they were gripping at 50 percent of their maximum capacity for as long as they could.
At the end of the hand-grip exercise, the blood pressure cuff on the participant’s arm was inflated, almost instantly trapping the metabolites generated by the exercise within the forearm muscles. This allowed the metabolites to collect in the forearm tissue without being cleared by the circulatory system. There, the metabolites continued to activate fatigue pathways, sending messages of fatigue to the brain and allowing researchers to measure how much fatigue and pain may occur because of the trapped metabolites.
With the blood pressure cuff still inflated, the participants rated fatigue and then pain in their forearms every 30 seconds. Both patients with SEID and patients without the disease reported increasing fatigue, but patients with the disease recorded much higher levels of fatigue and pain.
Patients with SEID rated their fatigue at approximately 5.5 on a scale of 0 to 10 after the hand-grip exercise while wearing the inflated blood pressure cuff, whereas participants without the disease rated their fatigue at approximately 1.5.
After 30 minutes, the participants repeated the exercise, but with the opposite arm and without the cinching blood pressure cuff so the metabolites could be cleared from the arm. Both sets of participants experienced fatigue, but the feeling of fatigue in those with the disease was much lower than when the metabolites were trapped with the blood pressure cuff.
“This suggests that hypersensitive fatigue pathways play an important role for the often pronounced exercise-related fatigue of patients with the disease,” Staud said.
Next, Staud plans to explore treatment interventions and